Plant-Derived Human Vaccines: Recent Developments.

ABSTRACT: The idea of producing vaccines in plants originated in the late 1980s. Initially, it was contemplated that this notion could facilitate the concept of edible vaccines, making them more cost effective and easily accessible. Initial studies on edible vaccines focussed on the use of a variety of different transgenic plant host species for the production of vaccine antigens. However, adequate expression levels of antigens, the difficulties predicted with administration of consistent doses, and regulatory rules required for growth of transgenic plants gave way to the development of vaccine candidates that could be purified and administered parenterally. The field has subsequently advanced with improved expression techniques including a shift from using transgenic to transient expression of anti

SUBMITTER: Stander J 

PROVIDER: S-EPMC9275545 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature