Seminal Microbiota of Idiopathic Infertile Patients and Its Relationship With Sperm DNA Integrity.

ABSTRACT: The development of new biomarkers for human male infertility is crucial to improve the diagnosis and the prognosis of this disease. Recently, seminal microbiota was shown to be related to sperm quality parameters, suggesting an effect in human fertility and postulating it as a biomarker candidate. However, its relationship to sperm DNA integrity has not been studied yet. The aim of the present study is to characterize the seminal microbiota of a western Mediterranean population and to evaluate its relationship to sperm chromatin integrity parameters, and oxidative stress. For that purpose, 14 samples from sperm donors and 42 samples from infertile idiopathic patients were obtained and were analyzed to assess the composition of the microbiota through full-length 16S rRNA gene sequenc

SUBMITTER: Garcia-Segura S 

PROVIDER: S-EPMC9275566 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature