Evaluating a pragmatic estimate of insulin sensitivity in Latino youth with obesity.

ABSTRACT: The whole-body insulin sensitivity index (WBISI) is a widely used surrogate of insulin sensitivity estimated from glucose and insulin concentrations during an oral glucose tolerance test (OGTT). The original WBISI uses five timepoints but reduced sampling models have been proposed. These reduced models have not been applied to the paediatric population. The purpose of this study is to compare cross-sectional agreement and changes in response to lifestyle intervention between the original WBISI and the WBISI₁₂₀ using fasting and 2-hour glucose and insulin concentrations from OGTT among Latino adolescents with obesity. We also examined the cost-differential between the two measures. Secondary analyses were conducted with data from Latino adolescents (14-16 years) with obesity (BMI

SUBMITTER: Pena A 

PROVIDER: S-EPMC9275660 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature