The essential Rhodobacter sphaeroides CenKR two-component system regulates cell division and envelope biosynthesis.

ABSTRACT: Bacterial two-component systems (TCSs) often function through the detection of an extracytoplasmic stimulus and the transduction of a signal by a transmembrane sensory histidine kinase. This kinase then initiates a series of reversible phosphorylation modifications to regulate the activity of a cognate, cytoplasmic response regulator as a transcription factor. Several TCSs have been implicated in the regulation of cell cycle dynamics, cell envelope integrity, or cell wall development in Escherichia coli and other well-studied Gram-negative model organisms. However, many α-proteobacteria lack homologs to these regulators, so an understanding of how α-proteobacteria orchestrate extracytoplasmic events is lacking. In this work we identify an essential TCS, CenKR (Cell envelope Kinase and Regu

SUBMITTER: Lakey BD 

PROVIDER: S-EPMC9275681 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature