Investigating latent syphilis in HIV treatment-experienced Ethiopians and response to therapy.

ABSTRACT:

Objectives

We investigated people with HIV (PWH) receiving combination antiretroviral therapy (cART) for latent syphilis infection prevalence, risk factors, treatment response, and neurosyphilis.

Methods

A prospective follow-up study was conducted on PWH and latent syphilis. The cases were randomly assigned to receive either benzathine penicillin G (BPG) or doxycycline (DOXY), and the posttreatment response was evaluated after 12 and 24 months. The traditional algorithm was used for serodiagnosis, and a semi-quantitative rapid plasma reagin (RPR) test monitored disease activity and treatment effectiveness.

Results

Of the 823 participants, 64.8% were women, and the mean age was 41.7±10 years. Thirty-one (3.8%) of the participants (22 males and nine females) had latent

SUBMITTER: Girma S 

PROVIDER: S-EPMC9275702 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature