Multi-stage analysis of FOXM1, PYROXD1, hTERT, PPARA, PIM3, BMI1 and MCTP1 expression patterns in colorectal cancer.

ABSTRACT:

Aim

To explore biomarkers with a tumor stage-dependent expression pattern in patients with colorectal cancer (CRC).

Background

The fourth most common cancer in the world is colorectal cancer (CRC). A variation in the gene expression rate is a common change in cancers initiation and the accumulation of these variation changes the behavior of normal cells and turns them into cancer cells.

Methods

Real-time RT-PCR was used to investigate the expression patterns of the FOXM1, PYROXD1, hTERT, BMI, PPARA, PIM3 and MCTP1 genes in 54 patients with stage I to IV CRC and their relation with clinicopathological features of CRC were analyzed. Results: FOXM1, hTERT and MCTP1 genes are overexpressed in CRC tumor

SUBMITTER: Shabani S 

PROVIDER: S-EPMC9275742 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature