Pancreatic Ductal Carcinoma Risk Associated With Hereditary Cancer-Risk Genes.

ABSTRACT:

Background

Although several hereditary cancer predisposition genes have been implicated in pancreatic ductal adenocarcinoma (PDAC) susceptibility, gene-specific risks are not well defined and are potentially biased because of the design of previous studies. More precise and unbiased risk estimates can result in screening and prevention better tailored to genetic findings.

Methods

This is a retrospective analysis of 676 667 individuals, 2445 of whom had a personal diagnosis of PDAC, who received multigene panel testing between 2013 and 2020 from a single laboratory. Clinical data were obtained from test requisition forms. Multivariable logistic regression models determined the increased risk of PDAC because of pathogenic variants (PVs) in various genes as adjusted odds ratios

SUBMITTER: Gardiner A 

PROVIDER: S-EPMC9275755 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature