Quantitative Nodal Burden and Mortality Across Solid Cancers.

ABSTRACT:

Background

Nodal staging systems vary substantially across solid tumors, implying heterogeneity in the behavior of nodal variables in various contexts. We hypothesized, in contradiction to this, that metastatic lymph node (LN) number is a universal and dominant predictor of outcome across solid tumors.

Methods

We performed a retrospective cohort analysis of 1 304 498 patients in the National Cancer Database undergoing surgery between 2004 and 2015 across 16 solid cancer sites. Multivariable Cox regression analyses were constructed using restricted cubic splines to model the association between nodal number and mortality. Recursive partitioning analysis (RPA) was used to derive nodal classification systems for each solid cancer based on metastatic LN count. The reproducibilit

SUBMITTER: Nguyen AT 

PROVIDER: S-EPMC9275768 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature