Melanoma brain metastasis presentation, treatment, and outcomes in the age of targeted and immunotherapies.

ABSTRACT:

Background

Historically, the prognosis for patients who have melanoma brain metastasis (MBM) has been dismal. However, breakthroughs in targeted and immunotherapies have improved long-term survival in those with advanced melanoma. Therefore, MBM presentation, prognosis, and the use of multimodality central nervous system (CNS)-directed treatment were reassessed.

Methods

In this retrospective study, the authors evaluated patients with MBM who received treatment at Memorial Sloan Kettering Cancer Center between 2010 and 2019. Kaplan-Meier methodology was used to describe overall survival (OS). Recursive partitioning analysis and time-dependent multivariable Cox modeling were used to assess prognostic variables and to associate CNS-directed treatments with OS.

Results

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SUBMITTER: Bander ED 

PROVIDER: S-EPMC9275782 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature