Acquired von Willebrand Syndrome and Desmopressin Resistance During Venovenous Extracorporeal Membrane Oxygenation in Patients With COVID-19: A Prospective Observational Study.

ABSTRACT:

Objectives

Although COVID-19 is associated with high von Willebrand factor (vWF) parameters promoting thrombosis, venovenous extracorporeal membrane oxygenation (vvECMO) is associated with the development of acquired von Willebrand syndrome (AVWS) promoting bleeding. This study was designed to assess both the incidence and severity of AVWS in COVID-19 patients undergoing vvECMO, and the benefit of comprehensive vWF analyses.

Design

Prospective observational study.

Setting

ICU at a tertiary-care center.

Patients

Twenty-seven consecutive COVID-19 patients with acute respiratory distress syndrome (ARDS) requiring vvECMO.

Measurements and main results

Comprehensive vWF analyses (including sodium dodecyl-sulfate polyacrylamide gel electrophoresis) were perfor

SUBMITTER: Kalbhenn J 

PROVIDER: S-EPMC9275806 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature