Construction and validation of a robust ferroptosis-associated gene signature predictive of prognosis in lung adenocarcinoma.

ABSTRACT:

Abstract

To construct and validate a ferroptosis-associated signature predictive of prognosis in lung adenocarcinoma (LUAD), and systematically evaluate the underlying molecular connections in cancer biology.We retrieved mRNAs sequencing profiles of LUAD from the cancer genome atlas (TCGA) data portal and clinical information from the cBio Cancer Genomics Portal. The differentially expressed ferroptosis-associated genes (DEFAGs) were screened between normal samples and LUAD by packages "limma" in R. Then the total TCGA cohort was randomly divided into training set and testing set. Based on the training set, a DEFAG signature was built and further validated in the test set, the total TCGA cohort and other independent cohorts from the gene expression omnibus data portal. A nomogram w

SUBMITTER: Zhou M 

PROVIDER: S-EPMC9276120 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature