Psychiatric symptoms are not associated with circulating CRP concentrations after controlling for medical, social, and demographic factors.

ABSTRACT: Elevated serum concentrations (>3 mg/L) of the acute-phase protein, C-reactive protein (CRP), is used as a clinical marker of inflammation and is reported to be a strong risk factor for cardiovascular disease. In psychiatric populations, CRP concentration is reported to be higher in depressed versus healthy individuals. Positive associations between CRP and depression have been established in both clinical and community samples, but effect sizes are attenuated after controlling for confounding variables. Similarly, emerging research has begun to draw a link between inflammation, symptoms of anxiety, and substance abuse. Given the high level of comorbid anxiety and substance use disorders in many depressed populations, this study examined whether depression (Patient Health Questionnaire 9 [

SUBMITTER: Figueroa-Hall LK 

PROVIDER: S-EPMC9276683 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature