Time moderates the interplay between 5-HTTLPR and stress on depression risk: gene x environment interaction as a dynamic process.

ABSTRACT: The serotonin-transporter-linked promoter region (5-HTTLPR) has been widely investigated as contributing to depression vulnerability. Nevertheless, empirical research provides wide contrasting findings regarding its involvement in the etiopathogenesis of the disorder. Our hypothesis was that such discrepancy can be explained considering time as moderating factor. We explored this hypothesis, exploiting a meta analytic approach. We searched PubMed, PsychoINFO, Scopus and EMBASE databases and 1096 studies were identified and screened, resulting in 22 studies to be included in the meta-analyses. The effect of the 5-HTTLPR x stress interaction on depression risk was found to be moderated by the following temporal factors: the duration of stress (i.e. chronic vs. acute) and the time interval be

SUBMITTER: Delli Colli C 

PROVIDER: S-EPMC9276704 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature