Atomic-resolution structures from polycrystalline covalent organic frameworks with enhanced cryo-cRED.

ABSTRACT: The pursuit of atomic precision structure of porous covalent organic frameworks (COFs) is the key to understanding the relationship between structures and properties, and further developing new materials with superior performance. Yet, a challenge of how to determine their atomic structures has always existed since the first COFs reported seventeen years ago. Here, we present a universal method for ab initio structure determination of polycrystalline three-dimensional (3D) COFs at atomic level using enhanced cryo-continuous rotation electron diffraction (cryo-cRED), which combines hierarchical cluster analysis with cryo-EM technique. The high-quality datasets possess not only up to 0.79-angstrom resolution but more than 90% completeness, leading to unambiguous solution and precise refineme

SUBMITTER: Li J 

PROVIDER: S-EPMC9276740 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature