The amniotic fluid proteome predicts imminent preterm delivery in asymptomatic women with a short cervix.

ABSTRACT: Preterm birth, the leading cause of perinatal morbidity and mortality, is associated with increased risk of short- and long-term adverse outcomes. For women identified as at risk for preterm birth attributable to a sonographic short cervix, the determination of imminent delivery is crucial for patient management. The current study aimed to identify amniotic fluid (AF) proteins that could predict imminent delivery in asymptomatic patients with a short cervix. This retrospective cohort study included women enrolled between May 2002 and September 2015 who were diagnosed with a sonographic short cervix (< 25 mm) at 16-32 weeks of gestation. Amniocenteses were performed to exclude intra-amniotic infection; none of the women included had clinical signs of infection or labor at the time of amnioc

SUBMITTER: Gudicha DW 

PROVIDER: S-EPMC9276779 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature