The NHS England 100,000 Genomes Project: feasibility and utility of centralised genome sequencing for children with cancer.

ABSTRACT:

Background

Whole-genome sequencing (WGS) of cancers is becoming an accepted component of oncological care, and NHS England is currently rolling out WGS for all children with cancer. This approach was piloted during the 100,000 genomes (100 K) project. Here we share the experience of the East of England Genomic Medicine Centre (East-GMC), reporting the feasibility and clinical utility of centralised WGS for individual children locally.

Methods

Non-consecutive children with solid tumours were recruited into the pilot 100 K project at our Genomic Medicine Centre. Variant catalogues were returned for local scrutiny and appraisal at dedicated genomic tumour advisory boards with an emphasis on a detailed exploration of potential clinical value.

Results

Thirty-six children,

SUBMITTER: Trotman J 

PROVIDER: S-EPMC9276782 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature