The impact of oophorectomy on survival from breast cancer in patients with CHEK2 mutations.

ABSTRACT:

Background

To estimate the impact of oophorectomy and other treatments on the survival of breast cancer patients with a CHEK2 mutation.

Methods

Women with Stage I-III breast cancer who were treated at 17 hospitals in Poland were tested for four founder mutations in the CHEK2 gene. 974 women (10%) were positive for a CHEK2 mutation. Control patients without a CHEK2 mutation were selected from a database of patients treated over the same time period. Information on treatments received and distant recurrences were retrieved from medical records. Treatments included chemotherapy, hormonal therapy (tamoxifen) and radiation therapy. Oophorectomies were performed for the treatment of breast cancer or for benign conditions. Dates of death were obtained from the Polish Vital Statisti

SUBMITTER: Tomiczek-Szwiec J 

PROVIDER: S-EPMC9276789 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature