MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms.

ABSTRACT: MiR-21 was identified as a gene whose expression correlated with the extent of metastasis of murine mammary tumours. Since miR-21 is recognised as being associated with poor prognosis in cancer, we investigated its contribution to mammary tumour growth and metastasis in tumours with capacity for spontaneous metastasis. Unexpectedly, we found that suppression of miR-21 activity in highly metastatic tumours resulted in regression of primary tumour growth in immunocompetent mice but did not impede growth in immunocompromised mice. Analysis of the immune infiltrate of the primary tumours at the time when the tumours started to regress revealed an influx of both CD4⁺ and CD8⁺ activated T cells and a reduction in PD-L1⁺ infiltrating monocytes, providing an explan

SUBMITTER: Chi LH 

PROVIDER: S-EPMC9276829 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature