Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles.

ABSTRACT: Nanomedicine holds promise to enhance cancer immunotherapy; however, its potential to elicit highly specific anti-tumor immunity without compromising immune tolerance has yet to be fully unlocked. This study develops deep-tissue activatable cancer sono-immunotherapy based on the discovery of a semiconducting polymer that generates sonodynamic singlet oxygen (¹O₂) substantially higher than other sonosensitizers. Conjugation of two immunomodulators via ¹O₂-cleavable linkers onto this polymer affords semiconducting polymer immunomodulatory nanoparticles (SPINs) whose immunotherapeutic actions are largely inhibited. Under ultrasound irradiation, SPINs generate ¹O₂ not only to directly debulk tumors and reprogram tumor microenvir

SUBMITTER: Li J 

PROVIDER: S-EPMC9276830 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature