Lifestyle or Environmental Influences and Their Interaction With Genetic Susceptibility on the Risk of LADA.

ABSTRACT:

Background

LADA is a common form of diabetes described as a mix between type 1 and type 2 diabetes. Understanding of how genes and environmental factors interact in the development of LADA is central for future efforts to prevent the disease. This review aims to synthesize the literature on lifestyle factors linked to LADA risk and discuss their potential interaction with genetic susceptibility.

Findings

Current knowledge on environmental risk factors for LADA is primarily based on observational data from Scandinavian populations. Increasing evidence suggest that lifestyle factors promoting type 2 diabetes such as obesity, sedentariness, low birth weight and smoking, is implicated in the risk of LADA. Data from mendelian randomization studies support that the link between LA

SUBMITTER: Carlsson S 

PROVIDER: S-EPMC9276967 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature