Identification of Key Non-coding RNAs and Transcription Factors in Calcific Aortic Valve Disease.

ABSTRACT:

Background

Calcific aortic valve disease (CAVD) is one of the most frequently occurring valvular heart diseases among the aging population. Currently, there is no known pharmacological treatment available to delay or reverse CAVD progression. The regulation of gene expression could contribute to the initiation, progression, and treatment of CAVD. Non-coding RNAs (ncRNAs) and transcription factors play essential regulatory roles in gene expression in CAVD; thus, further research is urgently needed.

Materials and methods

The gene-expression profiles of GSE51472 and GSE12644 were obtained from the Gene Expression Omnibus database, and differentially expressed genes (DEGs) were identified in each dataset. A protein-protein-interaction (PPI) network of DEGs was then constructed u

SUBMITTER: Guo S 

PROVIDER: S-EPMC9276990 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature