PD-L1 Up-Regulation in Prostate Cancer Cells by Porphyromonas gingivalis.

ABSTRACT: Chronic inflammation is known to contribute to various human cancers. Porphyromonas gingivalis (P. gingivalis), is a gram-negative oral keystone pathogen that may cause severe periodontitis and expresses several virulence factors to affect the host immune system. Periodontitis is a chronic infectious disease that while progression, may cause loss of attachment and destruction of the tooth supporting tissues. Prostate cancer is one of the most common malignancies in men. Increasing evidence links periodontitis with prostate cancer, however the mechanisms explaining this relationship remain unclear. The aim of this study was to investigate the expression and signaling pathway of programmed death ligand 1 (PD-L1) in a prostate cancer cell line after infection with P. g

SUBMITTER: Groeger S 

PROVIDER: S-EPMC9277116 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature