Association of Nrf2 expression and mutation with Weiss and Helsinki scores in adrenocortical carcinoma.

ABSTRACT: Adrenocortical carcinoma (ACC) is a rare malignant tumor. Genetic abnormalities that may represent therapeutic targets and prognostic factors in ACC remain unclear. Besides being one of the main cellular defense mechanisms that regulates antioxidant pathways for detoxifying reactive oxygen species (ROS), the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) promotes tumor proliferation by increasing metabolic activity. In surgical specimens from 12 cases of nonmetastatic ACCs and nine cases of benign adrenocortical adenoma (ACA), we investigated gene mutation and protein expressions for Nrf2 and the preoperative maximum standard glucose uptake (SUVmax) on [¹⁸ F]fluorodeoxy-glucose positron emission tomography. Three of five ACCs with a Weiss score of 7 to 9

SUBMITTER: Kamai T 

PROVIDER: S-EPMC9277251 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature