Topological bio-scaling analysis as a universal measure of protein folding.

ABSTRACT: Scaling relationships for polymeric molecules establish power law dependencies between the number of molecular segments and linear dimensions, such as the radius of gyration. They also establish spatial topological properties of the chains, such as their dimensionality. In the spatial domain, power exponents α = 1 (linear stretched molecule), α = 0.5 (the ideal chain) and α = 0.333 (compact globule) are significant. During folding, the molecule undergoes the transition from the one-dimensional linear to the three-dimensional globular state within a very short time. However, intermediate states with fractional dimensions can be stabilized by modifying the solubility (e.g. by changing the solution temperature). Topological properties, such as dimension, correlate with th

SUBMITTER: Shityakov S 

PROVIDER: S-EPMC9277272 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature