Molecular Mechanisms of Epigenetic Regulation, Inflammation, and Cell Death in ADPKD.

ABSTRACT: Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder, which is caused by mutations in the PKD1 and PKD2 genes, characterizing by progressive growth of multiple cysts in the kidneys, eventually leading to end-stage kidney disease (ESKD) and requiring renal replacement therapy. In addition, studies indicate that disease progression is as a result of a combination of factors. Understanding the molecular mechanisms, therefore, should facilitate the development of precise therapeutic strategies for ADPKD treatment. The roles of epigenetic modulation, interstitial inflammation, and regulated cell death have recently become the focuses in ADPKD. Different epigenetic regulators, and the presence of inflammatory markers detectable even before cyst growth, have be

SUBMITTER: Agborbesong E 

PROVIDER: S-EPMC9277309 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature