Curcumin, thymoquinone, and 3, 3'-diindolylmethane combinations attenuate lung and liver cancers progression.

ABSTRACT: Cancer can develop due to abnormal cell proliferation in any body's cells, so there are over a hundred different types of cancer, each with its distinct behavior and response to treatment. Therefore, many studies have been conducted to slow cancer progression and find effective and safe therapies. Nutraceuticals have great attention for their anticancer potential. Therefore, the current study was conducted to investigate the anticancer effects of curcumin (Cur), thymoquinone (TQ), and 3, 3'-diindolylmethane (DIM) combinations on lung (A549) and liver (HepG2) cancer cell lines' progression. Results showed that triple (Cur + TQ + DIM) and double (Cur + TQ, Cur + DIM, and TQ + DIM) combinations of Cur, TQ, and DIM significantly increased apoptosis with elevation of caspase-3 protein levels. A

SUBMITTER: Saddiq AA 

PROVIDER: S-EPMC9277483 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature