Effect of angiotensin-converting enzyme inhibition on cardiovascular adaptation to exercise training.

ABSTRACT: Angiotensin-converting enzyme (ACE) activity may be one determinant of adaptability to exercise training, but well-controlled studies in humans without confounding conditions are lacking. Thus, the purpose of the present study was to investigate whether ACE inhibition affects cardiovascular adaptations to exercise training in healthy humans. Healthy participants of both genders (40 ± 7 years) completed a randomized, double-blind, placebo-controlled trial. Eight weeks of exercise training combined with placebo (PLA, n = 25) or ACE inhibitor (ACEi, n = 23) treatment was carried out. Before and after the intervention, cardiovascular characteristics were investigated. Mean arterial blood pressure was reduced (p < 0.001) by -5.5 [-8.4; -2.6] mmHg in ACE_i , whereas the 0.7 [-2.0; 3.5]

SUBMITTER: Sjurðarson T 

PROVIDER: S-EPMC9277514 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature