Ontology highlight
ABSTRACT:
SUBMITTER: Bonelli J
PROVIDER: S-EPMC9277592 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Bonelli Joaquín J Ortega-Forte Enrique E Rovira Anna A Bosch Manel M Torres Oriol O Cuscó Cristina C Rocas Josep J Ruiz José J Marchán Vicente V
Biomacromolecules 20220613 7
Integration of photosensitizers (PSs) within nanoscale delivery systems offers great potential for overcoming some of the "Achiles' heels" of photodynamic therapy (PDT). Herein, we have encapsulated a mitochondria-targeted coumarin PS into amphoteric polyurethane-polyurea hybrid nanocapsules (NCs) with the aim of developing novel nanoPDT agents. The synthesis of coumarin-loaded NCs involved the nanoemulsification of a suitable prepolymer in the presence of a PS without needing external surfactan ...[more]