Unknown

Dataset Information

0

Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane-Polyurea Hybrid Nanocarrier.


ABSTRACT: Integration of photosensitizers (PSs) within nanoscale delivery systems offers great potential for overcoming some of the "Achiles' heels" of photodynamic therapy (PDT). Herein, we have encapsulated a mitochondria-targeted coumarin PS into amphoteric polyurethane-polyurea hybrid nanocapsules (NCs) with the aim of developing novel nanoPDT agents. The synthesis of coumarin-loaded NCs involved the nanoemulsification of a suitable prepolymer in the presence of a PS without needing external surfactants, and the resulting small nanoparticles showed improved photostability compared with the free compound. Nanoencapsulation reduced dark cytotoxicity of the coumarin PS and significantly improved in vitro photoactivity with red light toward cancer cells, which resulted in higher phototherapeutic indexes compared to free PS. Importantly, this nanoformulation impaired tumoral growth of clinically relevant three-dimensional multicellular tumor spheroids. Mitochondrial photodamage along with reactive oxygen species (ROS) photogeneration was found to trigger autophagy and apoptotic cell death of cancer cells.

SUBMITTER: Bonelli J 

PROVIDER: S-EPMC9277592 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane-Polyurea Hybrid Nanocarrier.

Bonelli Joaquín J   Ortega-Forte Enrique E   Rovira Anna A   Bosch Manel M   Torres Oriol O   Cuscó Cristina C   Rocas Josep J   Ruiz José J   Marchán Vicente V  

Biomacromolecules 20220613 7


Integration of photosensitizers (PSs) within nanoscale delivery systems offers great potential for overcoming some of the "Achiles' heels" of photodynamic therapy (PDT). Herein, we have encapsulated a mitochondria-targeted coumarin PS into amphoteric polyurethane-polyurea hybrid nanocapsules (NCs) with the aim of developing novel nanoPDT agents. The synthesis of coumarin-loaded NCs involved the nanoemulsification of a suitable prepolymer in the presence of a PS without needing external surfactan  ...[more]

Similar Datasets

| S-EPMC9929546 | biostudies-literature
| S-EPMC5588099 | biostudies-literature
| S-EPMC7020795 | biostudies-literature
| S-EPMC4648641 | biostudies-literature
| S-EPMC9906708 | biostudies-literature
| S-EPMC9419188 | biostudies-literature
| S-EPMC8667040 | biostudies-literature
| S-EPMC7139909 | biostudies-literature
| S-EPMC8533469 | biostudies-literature
| S-EPMC8381541 | biostudies-literature