Plant miR167e-5p promotes 3T3-L1 adipocyte adipogenesis by targeting β-catenin.

ABSTRACT: Adipogenesis is important in the development of fat deposition. Evidence showed that plant microRNAs (miRNAs) could be absorbed by the digestive tract and exert regulatory effects on animals' physiological processes. However, the regulation of plant miRNA on host lipogenesis remains unknown. This study explored the potential function of plant miRNA, miR167e-5p, in adipogenesis in vitro. The presentation of plant miR167e-5p improved lipid accumulation in 3T3-L1 cells. Bioinformatics prediction and luciferase reporter assay indicated that miR167e-5p targeted β-catenin. MiR167e-5p could not only negatively affect the expression of β-catenin but also showed a positive effect on several fat synthesis-related genes, peroxisome proliferator-activated receptor gamma (Pparγ), CCAAT/enhancer-binding

SUBMITTER: Chen T 

PROVIDER: S-EPMC9277600 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature