Digesting the Role of JAK-STAT and Cytokine Signaling in Oral and Gastric Cancers.

ABSTRACT: When small proteins such as cytokines bind to their associated receptors on the plasma membrane, they can activate multiple internal signaling cascades allowing information from one cell to affect another. Frequently the signaling cascade leads to a change in gene expression that can affect cell functions such as proliferation, differentiation and homeostasis. The Janus kinase-signal transducer and activator of transcription (JAK-STAT) and the tumor necrosis factor receptor (TNFR) are the pivotal mechanisms employed for such communication. When deregulated, the JAK-STAT and the TNF receptor signaling pathways can induce chronic inflammatory phenotypes by promoting more cytokine production. Furthermore, these signaling pathways can promote replication, survival and metastasis of cancer cell

SUBMITTER: Ni Y 

PROVIDER: S-EPMC9277720 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature