Myasthenia gravis in pregnancy: Systematic review and case series.

ABSTRACT:

Background

Myasthenia gravis is an autoimmune disease which can impact pregnancy.

Methods

Six databases were systematically searched for studies with at least five subjects reporting pregnancy outcomes for women with myasthenia gravis in pregnancy. Assessment of bias was performed for all included studies. Forty-eight cases from our own centre were also included in the analysis.

Results

In total, 32 publications met inclusion criteria for systematic review, for a total of 33 unique data sets including 48 cases from our institution. Outcome data was available for 824 pregnancies. Spontaneous vaginal delivery occurred in 56.3% of pregnancies. Overall risk of myasthenia gravis exacerbation was 33.8% with a 6.4% risk of myasthenic crisis in pregnancy and 8.2% postpartum.

SUBMITTER: Banner H 

PROVIDER: S-EPMC9277733 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature