A systematic review and meta-analysis of blood interleukin-4 levels concerning malaria infection and severity.

ABSTRACT:

Background

Interleukin (IL)-4 had been linked to malaria severity, but the findings are controversial, and the evidence is inconsistent and imprecise. In the current investigation, data on IL-4 levels in patients with severe and uncomplicated malaria were compiled.

Methods

The systematic review was registered at PROSPERO (CRD42022323387). Searches for relevant articles on IL-4 levels in patients with severe malaria and studies that examined IL-4 levels in both uncomplicated malaria and healthy controls were performed in PubMed, Embase, and Scopus using the search strategy without limitation to publication years or language. The quality of all included studies was evaluated using The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: stan

SUBMITTER: Kotepui KU 

PROVIDER: S-EPMC9277793 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature