CircCYP24A1 promotes Docetaxel resistance in prostate Cancer by Upregulating ALDH1A3.

ABSTRACT:

Background

Docetaxel (DTX) is the most widely prescribed first-line chemotherapy for advanced prostate cancer (PCa). Unfortunately, DTX resistance invariably emerges, leading to worse prognosis of PCa. Growing evidence has shown that circRNAs had complex spatiotemporal specificity during the tumor development and oncogenesis. This study was designed to investigate the biological functions and possible molecular mechanisms of circRNAs in DTX resistance of PCa.

Methods

circRNAs in established DTX-resistant DU145 cell line were identified by RNA sequencing. Biological function of circCYP24A1 was verified in vitro and in vivo. The potential role of circCYP24A1 in the development of DTX-resistant PCa was investigated via dual-luciferase reporter assays, RIP assays and RNA pull-do

SUBMITTER: Yin H 

PROVIDER: S-EPMC9277795 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature