Comparison of dimethyl fumarate and interferon outcomes in an MS cohort.

ABSTRACT:

Background

To compare the effectiveness of dimethyl fumarate (DMF) with subcutaneous interferon beta-1a (IFNβ-1a) in controlling disease activity in patients with relapsing-remitting Multiple Sclerosis (MS).

Methods

Clinical and imaging data from patients treated with either IFNβ-1a or DMF for at least one year were reviewed. The proportion of patients with at least one clinical relapse within 3-15 months after treatment onset, the proportion of patients with new T2 or gadolinium-enhancing lesions, and the proportion of subjects who achieved no evidence of disease activity (NEDA) status were assessed.

Results

Three hundred sixteen (98 on IFNβ-1a, 218 on DMF) subjects were included. Baseline demographics were comparable between groups except for age, disease duration,

SUBMITTER: Sattarnezhad N 

PROVIDER: S-EPMC9277810 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature