The developing airway and gut microbiota in early life is influenced by age of older siblings.

ABSTRACT:

Background

Growing up with siblings has been linked to numerous health outcomes and is also an important determinant for the developing microbiota. Nonetheless, research into the role of having siblings on the developing microbiota has mainly been incidental.

Results

Here, we investigate the specific effects of having siblings on the developing airway and gut microbiota using a total of 4497 hypopharyngeal and fecal samples taken from 686 children in the COPSAC₂₀₁₀ cohort, starting at 1 week of age and continuing until 6 years of age. Sibship was evaluated longitudinally and used for stratification. Microbiota composition was assessed using 16S rRNA gene amplicon sequencing of the variable V4 region. We found siblings in the home to be one of the most important de

SUBMITTER: Christensen ED 

PROVIDER: S-EPMC9277889 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature