Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

ABSTRACT:

Background

In many organisms, aging is characterized by a loss of mitochondrial homeostasis. Multiple factors such as respiratory metabolism, mitochondrial fusion/fission, or mitophagy have been linked to cell longevity, but the exact impact of each one on the aging process is still unclear.

Results

Using the deletion mutant collection of the fission yeast Schizosaccharomyces pombe, we have developed a genome-wide screening for mutants with altered chronological lifespan. We have identified four mutants associated with proteolysis at the mitochondria that exhibit opposite effects on longevity. The analysis of the respiratory activity of these mutants revealed a positive correlation between increased respiration rate and prolonged lifespan. We also found that the phenotype of

SUBMITTER: Vega M 

PROVIDER: S-EPMC9277893 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature