Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease.

ABSTRACT:

Background

Airway remodeling is a significant contributor to impaired lung function in chronic allergic airway disease. Currently, no therapy exists that is capable of targeting these structural changes and the consequent loss of function. In the context of chronic allergic inflammation, pericytes have been shown to uncouple from the pulmonary microvasculature, migrate to areas of inflammation, and significantly contribute to airway wall remodeling and lung dysfunction. This study aimed to elucidate the mechanism by which pulmonary pericytes accumulate in the airway wall in a model of chronic allergic airway inflammation.

Methods

Mice were subjected to a protocol of chronic airway inflammation driven by the common environmental aeroallergen house dust mite. Phenotypic change

SUBMITTER: Bignold R 

PROVIDER: S-EPMC9277926 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature