Generational synaptic functions of GABA_A receptor β3 subunit deteriorations in an animal model of social deficit.

ABSTRACT:

Background

Disruption of normal brain development is implicated in numerous psychiatric disorders with neurodevelopmental origins, including autism spectrum disorder (ASD). Widespread abnormalities in brain structure and functions caused by dysregulations of neurodevelopmental processes has been recently shown to exert adverse effects across generations. An imbalance between excitatory/inhibitory (E/I) transmission is the putative hypothesis of ASD pathogenesis, supporting by the specific implications of inhibitory γ-aminobutyric acid (GABA)ergic system in autistic individuals and animal models of ASD. However, the contribution of GABAergic system in the neuropathophysiology across generations of ASD is still unknown. Here, we uncover profound alterations in the expression and func

SUBMITTER: Chu MC 

PROVIDER: S-EPMC9277936 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature