Role of Chromatin Modifying Complexes and Therapeutic Opportunities in Bladder Cancer.

ABSTRACT:

Background

Chromatin modifying enzymes, mainly through post translational modifications, regulate chromatin architecture and by extension the underlying transcriptional kinetics in normal and malignant cells. Muscle invasive bladder cancer (MIBC) has a high frequency of alterations in chromatin modifiers, with 76% of tumors exhibiting mutation in at least one chromatin modifying enzyme [1]. Additionally, clonal expansion of cells with inactivating mutations in chromatin modifiers has been identified in the normal urothelium, pointing to a currently unknown role of these proteins in normal bladder homeostasis.

Objective

To review current knowledge of chromatin modifications and enzymes regulating these processes in Bladder cancer (BCa).

Methods

By reviewing current lit

SUBMITTER: Meghani K 

PROVIDER: S-EPMC9278011 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature