An Activatable ¹⁹ F MRI Molecular Probe for Sensing and Imaging of Norepinephrine.

ABSTRACT: Norepinephrine (NE), acting as both a neurotransmitter and hormone, plays a significant role in regulating the action of the brain and body. Many studies have demonstrated a strong correlation between mental disorders and aberrant NE levels. Therefore, it is of urgent demand to develop in vivo analytical methods of NE for diagnostic assessment and mechanistic investigations of mental diseases. Herein, we report a ¹⁹ F MRI probe (NRFP) for sensing and imaging NE, which is constructed by conjugating a gadolinium chelate to a fluorine-containing moiety through a NE-responsive aromatic thiocarbonate linkage. The capacity and specificity of NRFP for detecting NE is validated with in vitro detecting/imaging experiments. Furthermore, the feasibility of NRFP for visualizing NE in animal

SUBMITTER: Li L 

PROVIDER: S-EPMC9278097 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature