Ligand-dependent, palladium-catalyzed stereodivergent synthesis of chiral tetrahydroquinolines.

ABSTRACT: The most fundamental tasks in asymmetric synthesis are the development of fully stereodivergent strategies to access the full complement of stereoisomers of products bearing multiple stereocenters. Although great progress has been made in the past few decades, developing general and practical strategies that allow selective generation of any diastereomer of a reaction product bearing multiple stereocentres through switching distinct chiral catalysts is a significant challenge. Here, attaining precise switching of the product stereochemistry, we develop a novel P-chirogenic ligand, i.e.YuePhos, which can be easily derived from inexpensive and commercially available starting materials in four chemical operations. Through switching of three chiral ligands, an unprecedented ligan

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9278114 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature