Relative Virulence of SARS-CoV-2 Among Vaccinated and Unvaccinated Individuals Hospitalized with SARS-CoV-2.

ABSTRACT:

Background

The rapid development of safe and effective vaccines against the SARS-CoV-2 virus has been a singular scientific achievement. Confounding due to health seeking behaviours, circulating variants, and differential testing by vaccination status may bias analyses towards an apparent increase in infection severity following vaccination.

Methods

We used data from Ontario, Canada's Case and Contact Management database, merged to a provincial vaccination dataset (COVaxON) to create a time-matched cohort of individuals who were hospitalized with SARS-CoV-2 infection. Vaccinated individuals were matched to up to five unvaccinated individuals based on test date. Risk of ICU admission and death were evaluated using conditional logistic regression. Unmatched exploratory analyse

SUBMITTER: Grima AA 

PROVIDER: S-EPMC9278128 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature