The Association Between Psoriasis and Risk of Cardiovascular Disease: A Mendelian Randomization Analysis.

ABSTRACT:

Background

A large number of observational studies showed that patients with psoriasis have a higher risk of cardiovascular disease (CVD), but most studies did not fully adjust for confounding factors, so it is not clear whether the risk of CVD is directly attributed to psoriasis. We used Mendelian randomization (MR) to evaluate the potential causal relationship between psoriasis and CVD.

Methods

We used genetic instruments from the genome-wide association study (GWAS) of European descent for psoriasis to investigate its relationship with CVD. Inverse variance-weighted (IVW) MR analyses were used for the primary analysis. In addition, a variety of other methods were used to replicate the analysis.

Results

The fixed-effects IVW method indicated that genetic susceptibil

SUBMITTER: Gao N 

PROVIDER: S-EPMC9278135 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature