Comparative COVID-19 Vaccine Effectiveness Over Time in Veterans.

ABSTRACT:

Background

Comparative effectiveness of coronavirus disease 2019 (COVID-19) vaccines across patient subgroups is poorly understood and essential to precisely targeting vaccination strategies.

Methods

We used the US Department of Veterans Affairs COVID-19 Shared Data Resource to identify veterans who utilize VA health care and had no documented severe acute respiratory syndrome coronavirus 2 infection before December 11, 2020. Using a test-negative case-control design (TND), we used conditional logistic regression with adjustment for covariates to estimate vaccine effectiveness (VE) over time for veterans who received 2 doses of mRNA vaccines or 1 dose of Ad26.Cov2.S.

Results

We identified 4.8 million veterans with a mean age of 64 years, of whom 58% had ≥1 chronic dis

SUBMITTER: Mayr FB 

PROVIDER: S-EPMC9278190 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature