Interplay between demographic, clinical and polygenic risk factors for severe COVID-19.

ABSTRACT:

Background

We aimed to identify clinical, socio-demographic and genetic risk factors for severe COVID-19 (hospitalization, critical care admission or death) in the general population.

Methods

In this observational study, we identified 9560 UK Biobank participants diagnosed with COVID-19 during 2020. A polygenic risk score (PRS) for severe COVID-19 was derived and optimized using publicly available European and trans-ethnic COVID-19 genome-wide summary statistics. We estimated the risk of hospital or critical care admission within 28 days or death within 100 days following COVID-19 diagnosis, and assessed associations with socio-demographic factors, immunosuppressant use and morbidities reported at UK Biobank enrolment (2006-2010) and the PRS. To improve biological understand

SUBMITTER: Crossfield SSR 

PROVIDER: S-EPMC9278202 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature