Anti-membrane antibodies persist at least one year and discriminate between past COVID-19 infection and vaccination.

ABSTRACT: The consequences of past COVID-19 infection for personal and population health are emerging, but accurately identifying distant infection is a challenge. Anti-spike antibodies rise after both vaccination and infection and anti-nucleocapsid antibodies rapidly decline. We evaluated anti-membrane antibodies in COVID-19 naïve, vaccinated, and convalescent subjects to determine if they persist and accurately detect distant infection. We found that anti-membrane antibodies persist for at least a year and are a sensitive and specific marker of past COVID-19 infection. Thus, anti-membrane and anti-spike antibodies together can differentiate between COVID-19 convalescent, vaccinated, and naïve states to advance public health and research.

SUBMITTER: Amjadi MF 

PROVIDER: S-EPMC9278254 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature