Interaction of von Willebrand factor with blood cells in flow models: a systematic review.

ABSTRACT: The presence of blood flow influences the interaction between von Willebrand factor (VWF) and blood cells, affecting characteristics of forming blood clots. The interactions between coagulation and inflammation have mainly been studied in thrombosis models, but it remains unclear whether these interactions might also play a role in reduced bleeding in patients with bleeding disorders. In this systematic review, we provide an overview of the literature investigating the interactions between VWF and blood cells in flow models. For article selection, a systematic search was performed in Embase, Medline-Ovid, Cochrane Library, Web of Science databases, and Google Scholar. After selection, 24 articles were included. These articles describe direct or platelet-dependent interactions between VWF a

SUBMITTER: Arisz RA 

PROVIDER: S-EPMC9278308 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature