Mistic: An open-source multiplexed image t-SNE viewer.

ABSTRACT: Understanding the complex ecology of a tumor tissue and the spatiotemporal relationships between its cellular and microenvironment components is becoming a key component of translational research, especially in immuno-oncology. The generation and analysis of multiplexed images from patient samples is of paramount importance to facilitate this understanding. Here, we present Mistic, an open-source multiplexed image t-SNE viewer that enables the simultaneous viewing of multiple 2D images rendered using multiple layout options to provide an overall visual preview of the entire dataset. In particular, the positions of the images can be t-SNE or UMAP coordinates. This grouped view of all images allows an exploratory understanding of the specific expression pattern of a given biomarker or collec

SUBMITTER: Prabhakaran S 

PROVIDER: S-EPMC9278502 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature