DeepND: Deep multitask learning of gene risk for comorbid neurodevelopmental disorders.

ABSTRACT: Autism spectrum disorder and intellectual disability are comorbid neurodevelopmental disorders with complex genetic architectures. Despite large-scale sequencing studies, only a fraction of the risk genes was identified for both. We present a network-based gene risk prioritization algorithm, DeepND, that performs cross-disorder analysis to improve prediction by exploiting the comorbidity of autism spectrum disorder (ASD) and intellectual disability (ID) via multitask learning. Our model leverages information from human brain gene co-expression networks using graph convolutional networks, learning which spatiotemporal neurodevelopmental windows are important for disorder etiologies and improving the state-of-the-art prediction in single- and cross-disorder settings. DeepND identifies the pr

SUBMITTER: Beyreli I 

PROVIDER: S-EPMC9278518 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature