Coeliac disease re-screening among once seronegative at-risk relatives: A long-term follow-up study.

ABSTRACT:

Background

Serological screening of the relatives of coeliac disease patients is widely endorsed. However, the need for and the optimal timing of possible re-testing of once seronegative at-risk individuals for coeliac disease remain unclear.

Objective

We investigated this issue by inviting a large cohort of previously screening-negative relatives of patients with coeliac disease to participate in a follow-up study.

Methods

Altogether 599 relatives of coeliac disease index patients not diagnosed with coeliac disease in a screening study carried out in 2006-2010 were asked about possible later diagnosis or re-tested with coeliac disease autoantibodies in 2017-2021. Besides incidence, the possible impact of various patient-related clinical factors and HLA haplotype on t

SUBMITTER: Paavola S 

PROVIDER: S-EPMC9278577 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature